DetoxGen - Preventive Genetic Profile for phase I and II detoxification
This test analyses key genes involved in xenobiotics and drug metabolism, e.g. detoxification of insecticides, herbicides, nicotine, alcohol and carcinogenic substrates. DetoxGen is especially appropriate as a basic profile for anti-ageing treatment and allows to improve your detoxification capacities in order to prevent environmental diseases.
What is detoxification?
Detoxification is the mechanism of inactivation and elimination of waste products originating either from endogenous molecules such as hormones or from exogenous compounds such as drugs and pollutants. These eventually toxic waste products are chemically reduced or oxidised and finally conjugated in order to transform them into less toxic substances and to facilitate their excretion. The liver plays a crucial role in the detoxification processes (elimination of toxins, synthesis and secretion of bile, enzymatic disassemblage of chemicals). Other organs implicated in detoxification are the colon and the kidneys, but also the brain and the skin.
What are the consequences?
At the level of detoxification phase I Phase I neutralises toxins to form activated intermediate compounds. A dysfunction of the enzymatic activity leads to an inadequate metabolisation with unwanted side effects as a consequence. At the level of detoxification phase II Bioactivated substances from detoxification phase I are transformed (neutralised) into soluble compounds by phase II enzymes. Exposure to carcinogenic compounds coupled to a low enzymatic activity of phase II significantly increase the susceptibility to chronic diseases due to ageing.
The Test DetoxGen analyses several genetic variations linked to:
• the metabolic activation of polycyclic aromatic hydrocarbons
• the drug metabolism and cholesterol synthesis
• the detoxification of herbicides, insecticides and nicotine
• the detoxification of alcohol and the metabolism of toxic compounds
• the oxidation of steroids, fatty acids and xenobiotics
• the protection of cells against carcinogenic chemical compounds and/or xenobiotics via conjugation
• the detoxification of several substances originating from industrial pollution, tobacco consumption, etc.
Detailed dietary recommendations based on the genetic predispositions as well as on the patient’s questionnaire (non-genetic predispositions) allow a personalised prevention, guiding your healthcare practitioner to the protocol tailored to your genetics.